Gain-of-function genetic perturbationssimultaneouslyacross500 barcoded cancer cell lines
收藏NIAID Data Ecosystem2026-05-01 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE238126
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Using thisapproach, wequeriedthe pan-cancer vulnerability landscape upon activating 10key pathway nodes, revealing selectiveactivation dependenciesof MAPK and PI3K pathwaysassociatedwith specific biomarkers To profile activation of the curated gene sets across a broad panel of cell lines, we developed a high-throughput method for systematically examining the growth-suppressive effect of ORF expression in ~500 cancer cell lines. We next tested the perturbation effects of 11 ORFs (including GFP as a negative control) by lentiviral infection of each ORF encoding virus into separate pools of 488 cell lines.
创建时间：
2023-10-16
