Comprehensive identification and characterization of the binding sites of HIF-1alpha in mammalian genes were attempted. We used ChIP-Seq method, in which next gene sequencing technology and chromatin-
Motif discovery is essential for deciphering regulatory codes from high throughput genomic data, such as those from ChIP-chip/seq experiments. However, there remains a lack of effective and efficient
Evolution of gene regulation is crucial for our understanding of the phenotypic differences between species, populations and individuals. Sequence-specific binding of transcription factors to the regu
