Combined heterozygous loss of Ebf1 and Pax5 allows for T-lineage conversion of B-cell progenitors

ChEBI2015-05-27 更新2026-07-12 收录

淋巴细胞发育

细胞谱系重编程

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Combined heterozygous loss of Ebf1 and Pax5 allows for T-lineage conversion of B-cell progenitors

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2015-05-27

Conversion of MyoD to a neurogenic factor: binding site specificity determines lineage [ChIP-seq]. Mus musculus

细胞谱系重编程

转录因子结合

MyoD and NeuroD2 are master regulators of myogenesis and neurogenesis and bind to a "shared" E-box sequence (CAGCTG) and a "private" sequence (CAGGTG or CAGATG, respectively). To determine whether pri

NIAID Data Ecosystem70

The HDAC7-TET2 epigenetic axis is essential during early B lymphocyte development. The HDAC7-TET2 epigenetic axis is essential during early B lymphocyte development

淋巴细胞发育

表观遗传调控

B lymphopoiesis is the result of several cell lineage choices and differentiation steps whose perturbation leads to B cell malignancies. Cellular transitions for B cell generation have been associated

NIAID Data Ecosystem50

Regulation of B lymphocyte development by histone H2A deubiquitinase BAP1 (BAP1_ChIP-Seq)

淋巴细胞发育

泛素化调控

BAP1 is a deubiquitinase (DUB) of the Ubiquitin C-terminal Hydrolase (UCH) family that regulates gene expression and other cellular processes, via deubiquitination of histone H2AK119ub and other subst

NIAID Data Ecosystem50

IL-7Rα and E47: independent pathways required for development of multipotent lymphoid progenitors

淋巴细胞发育

转录因子信号通路

Mice that lack the transcription factors encoded by the E2A gene or the receptor for interleukin 7 (IL-7R) have severe overlapping defects in lymphocyte development. Here, we show that E2A proteins ar

PubMed Central2002-01-15 更新60

The Genetic Networks that Orchestrate Development of Specific Waves of Fetal and Adult B-1 and B-2 Development are Distinct. Mus musculus

淋巴细胞发育

转录调控网络

B lymphocyte development is often depicted as a linear process that initiates in the fetus and continues in the bone marrow after birth. Based on the dissection of B lymphopoiesis in a PU.1 hypomorphi

NIAID Data Ecosystem50

Combined heterozygous loss of Ebf1 and Pax5 allows for T-lineage conversion of B-cell progenitors

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