Raw concentration data - Serum metabolomic features of diabetic retinopathy in glucose well-controlled diabetic patients

To investigate systematic metabolic biomarkers for early diagnosis of glucose-well-controlled DM patients who still developed diabetic retinopathy (GW-DR) and explore potential biomarker-based precise treatment strategies for DR, a prospective hospital-based diabetes cohort was established at the Department of endocrinology and metabolism at Shanghai General Hospital. a total of 2126 diabetic patients have been recruited to receive diabetes management including glycemia control and regular follow-up care. A total of 42 glucose well-controlled diabetic participants, including 21 GW-DR subjects and 21 control subjects (GW-C) with matched HbA1c, fasting blood glucose (FBG), homeostasis model assessment for insulin resistance (HOMA-IR), homeostasis model assessment-b (HOMA-b), age, body mass index (BMI), and other clinical information both at baseline and follow-up using propensity score matching (PSM) were enrolled for serum metabolites analysis. To reveal the metabolic features of GW-DR patients, we used liquid chromatography-mass spectrometry to profile the metabolomic patterns in the serum of GW-DR and GW-C subjects.