Total Synthesis of (+)-Pleuromutilin
收藏NIAID Data Ecosystem2026-03-10 收录
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https://figshare.com/articles/dataset/Total_Synthesis_of_-Pleuromutilin/5797179
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资源简介：
An 18-step synthesis
of the antibiotic (+)-pleuromutilin is disclosed.
The key steps of the synthesis include a highly stereoselective SmI2-mediated cyclization to establish the eight-membered ring
and a stereospecific transannular [1,5]-hydrogen atom transfer to
set the C10 stereocenter. This strategy was also used to prepare (+)-12-epi-pleuromutilin. The chemistry described here will enable
efforts to prepare new mutilin antibiotics.
创建时间：
2018-01-17
