Integrative Genomic Analysis Reveals Novel Regulatory Mechanisms of eyeless During Drosophila Eye Development

eyeless (ey) is one of the most critical transcription factors for initiating the entire eye development in Drosophila. However, the molecular mechanisms through which Ey regulates target genes and pathways have not been characterized at the genomic level. Using ChIP-Seq, we generated an endogenous Ey binding profile in Drosophila developing eyes. These data sets will serve as a valuable resource for future studies on Ey and eye development. Overall design: ChIP-Seq of endogenous eyeless, H3K4me1, H3K18Ac, H3K27Ac and PolII in developing Drosophila late third instar eye discs.