Downregulated proteins in N. gonorrhoeae biofilms listed by functional rolesa: Biofilm/Planktonic ratios expressed as log2 values, 2-fold decrease (log2 values ≤−1.000) measured in at least one Extract, and p-values <0.05.

aFunctional role assignments (both main and JCVI sub-roles) for the N. gonorrhoeae proteins were downloaded from the JCVI-CMR website.bAverage log2 values for biofilm/planktonic protein ratios.c(N) represents the number of measurements (biological replicates) averaged.dProtein with more than one functional role assignment provided (Main role/JCVI sub-role): NGO0639, Energy metabolism/Glycolysis/gluconeogenesis.eProtein functional role category tentatively assigned in the present study by orthology to an N. meningitidis protein (see Supplementary Table S6 for details).