The prenatal nicotine exposure leads to epigenetic alterations in nervous system signaling genes in the rat [MeDIP]

Background. Prenatal exposure to nicotine has been documented to impose numerous deleterious effects on fetal development. However, the epigenetic changes promoted by nicotine exposure on germ cell are still not well understood. Objectives. In this study, we focused on elucidating the impact of prenatal nicotine exposure on regulatory epigenetic mechanisms important for the germ cells development. s important for the germ cells development研究背景：现有研究已证实，孕期尼古丁暴露可对胎儿发育造成诸多有害影响。然而，尼古丁暴露对生殖细胞（germ cell）诱导产生的表观遗传（epigenetic）改变机制，目前仍未得到充分阐明。 研究目的：本研究聚焦于阐明孕期尼古丁暴露对生殖细胞发育至关重要的调控性表观遗传机制所产生的影响。