Differential Gene Expression in Adgrl3 KO Mice

We report the differential expression of genes in Adgrl3 -/- mice in comparison to Adgrl3 +/+ mice. Three ADHD-relevant brain regions; hippocampus, pre-frontal cortex and striatum are included alongside a whole-brain analysis Examination of 3 independent brain regions in 2 genotypes. Combined analysis between genotypes across brain regions本研究报道了Adgrl3基因敲除（Adgrl3 -/-）小鼠与Adgrl3野生型纯合（Adgrl3 +/+）小鼠的基因差异表达水平。本研究纳入3个与注意缺陷多动障碍（ADHD）相关的脑区：海马体、前额叶皮层与纹状体，并同步开展全脑分析；同时对2种基因型小鼠的3个独立脑区进行检测，并开展跨脑区的基因型间联合分析。