Mutation is the source of genetic variation and fuels biological evolution. Many mutations first arise as DNA replication errors. These errors subsequently evade correction by cellular DNA repair, for

NIAID Data Ecosystem50

MMR gene alterations in cancer cell lines with determined MSI status.

肿瘤基因组学

DNA错配修复

Counts indicate the number of missense mutations in MMR genes, and cells with text in bold correspond to indels found in MMR genes.

Figshare2015-12-02 更新30

Crystal Structure of the MutS-ADPBeF3-DNA complex

DNA错配修复

DNA复合物

Crystal Structure of the MutS-ADPBeF3-DNA complex Descriptor: 1,2-ETHANEDIOL, 5'-D(*GP*CP*GP*AP*CP*GP*CP*TP*AP*GP*CP*GP*TP*GP*CP*GP*GP*CP*TP*CP*GP*TP*C)-3', 5'-D(P*GP*GP*AP*CP*GP*AP*GP*CP*CP*GP*CP*CP*

Protein Data Bank Japan2024-02-14 更新60

Anti-recombination function of MutSa restricts telomere extension by ALT-associated homology directed repair.

端粒替代延长

DNA错配修复

Alternative lengthening of telomeres (ALT) is a telomere elongation mechanism observed in ~15% of cancer subtypes. Current models indicate that ALT is mediated by homology-directed repair mechanisms.

NIAID Data Ecosystem40

Summary of MLH1 analyses from 31 fetal ovarian samples.

资源简介：

相关数据集