Post-slippage cells increase expression of factors associated with SASP.. Post-slippage cells increase expression of factors associated with SASP.

Human transcriptome analysis of U2OS cells treated with nocodazole or DMSO (Control). The gene expression profiling will reveal senescence-associated genes induced upon nocodazole treatment. Our preliminary data show that antimitotic drugs treatment promote post-slippage senescence. Overall design: We analyzed RNA samples extracted from treated cells using the Affymetrix Human Transcriptome 2.0 Arrays. Array data was processed by Partak genomic suite software. Two biological replicates were performed.