Prediction of novel relationships between biomedical concepts using the open discovery setting.

The following intermediate inclusion criteria were used to calculate the hidden relationships: minimal number of co-publications between keywords: at least 3; minimal R-scaled score between keywords: at least 20; intermediates used: genes (A and B), and genes, pathways and biological processes (C); literature: till May 1, 2007. The significance cutoff of Ri scores were set to a maximum false-positive rate of 0.1, which was set to 34 for disease-gene and drug-disease relationships, and set to 36 for drug-biological processes hidden relationships, as calculated in the literature partitioning analysis (Figure 2).