Crystal structure of the first bromodomain of human BRD4 in complex with the inhibitor 16k
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Crystal structure of the first bromodomain of human BRD4 in complex with the inhibitor 16k Descriptor: (7~{R})-2-[[2-ethoxy-4-(1-methylpiperidin-4-yl)phenyl]amino]-7-ethyl-5-methyl-8-[(4-methylthiophen-2-yl)methyl]-7~{H}-pteridin-6-one, 1,2-ETHANEDIOL, Bromodomain-containing protein 4 Authors: Heidenreich, D, Watts, E, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Knapp, S, Hoelder, S, Structural Genomics Consortium (SGC) Deposit date: 2018-12-04 Release date: 2019-03-06 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2 Å) Cite: Designing Dual Inhibitors of Anaplastic Lymphoma Kinase (ALK) and Bromodomain-4 (BRD4) by Tuning Kinase Selectivity. J.Med.Chem., 62, 2019
创建时间：
2018-12-04
