Targeting Transcriptional Addictions in Small Cell Lung Cancer with a Covalent CDK7 Inhibitor

NIAID Data Ecosystem2026-05-26 收录

小细胞肺癌转录成瘾

CDK7抑制剂

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA264540 数据链接链接失效反馈

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This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

创建时间：

2014-10-22

Global gene expression analysis in DMSO and THZ531 treated IMR32 and Kelly cells

神经母细胞瘤基因表达

CDK7抑制剂

We performed gene expression profiling by Affymetrix primeview array in both DMSO and THZ531 treated cells. Expression profiles of DMSO and THZ531 treated cells using GeneChip® PrimeView™ Human Gene

NIAID Data Ecosystem40

SY-1365, a covalent, first in-class CDK7 inhibitor for cancer treatment (microarray mRNA). SY-1365, a covalent, first in-class CDK7 inhibitor for cancer treatment (microarray mRNA)

癌症转录调控

CDK7抑制剂

Recent studies reveal that a subset of cancers in various indications are dependent on high and constant expression of certain transcription factors for growth and survival, a phenomenon termed as tra

NIAID Data Ecosystem30

Gene expression profiles of BxPC-3, MiaPaCa-2 and PANC-1 cell lines treated with DMSO and THZ1 respectively. Gene expression profiles of BxPC-3, MiaPaCa-2 and PANC-1 cell lines treated with DMSO and THZ1 respectively

胰腺癌药物机制

CDK7抑制剂

By screening an epigenetic-related compound library, we identified THZ1, a covalent inhibitor of CDK7, as a promising candidate. Multiple long-established and patient-derived PDAC cell lines (PDC) wer

NIAID Data Ecosystem20

CDK7-dependent Transcriptional Addiction in Triple-Negative Breast Cancer (Microarray)

三阴性乳腺癌转录调控

CDK7抑制剂

Triple-negative breast cancer (TNBC) is a highly aggressive form of breast cancer that exhibits extremely high levels of genetic complexity and yet a relatively uniform transcriptional program. We pos

NIAID Data Ecosystem40

Selective inhibition of CDK7 reveals the influence of CDK7 on psoriatic CD4+ T cells

银屑病

CDK7抑制剂

Purpose: The goals of this study are to compare the differential gene of psoriatic CD4+ T cells treated with THZ1 and DMSO Methods: RNA sequencing of psoriatic CD4+ T cells which treated with THZ1 (10

NIAID Data Ecosystem30

Targeting Transcriptional Addictions in Small Cell Lung Cancer with a Covalent CDK7 Inhibitor

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