NHLBI TOPMed: Children's Health Study (CHS) Integrative Genetic Approaches to Gene-Air Pollution Interactions in Asthma (GAP)

The Integrative Genetic Approaches to Gene-Air Pollution Interactions in Asthma (GAP) study was proposed to use an innovative genetics approach in mice and humans to identify novel variants that interact with traffic-related pollutant exposures to affect lung function phenotypes and the risk of childhood asthma. The study participants were enrolled from the original southern California Children's Health Study (CHS). In the TOPMed project, seven Hispanic White participants who did not have asthma history were included in the WGS analysis.]]>
TOPMed Whole Genome Sequencing Methods: Freeze 9TOPMed Whole Genome Sequencing Methods: Freeze 10The study population involves 120 young adults (over 18 years old) who had participated in the Southern California Children's Health Study (CHS) during 1993-2003 with previously collected genotyping data. We will enroll 120 age-, asthma- and gender-matched CHS subjects who live in high (n=30) and low (n=30) areas of traffic-related pollution exposure levels and who are homozygous for the non-effect allele (n=30) or carry at least one effect allele (n=30). For variants with sufficiently high effect allele frequencies, our strategy will be to recruit homozygotes for the non-effect (n=30) and effect (n=30) alleles in order to increase the likelihood of detecting a GxE interaction. Eligibility criteria for subjects' participation include a willingness and capability to perform the required test procedures, lack of a prior history of clinically significant chronic cardiorespiratory condition (except asthma), no current substantial occupational exposure to dusts, fumes or vehicle/diesel exhaust, and no current smoking or smoking history greater than one pack-year.]]>
Enrollment Years GAP: July 2012 to 2018]]>