QS-DMD

In this study, we developed a systematic workflow comprising three modules to construct a Quorum Sensing-based Drug-Microbe-Disease (QS-DMD) database ( http://www.qsdmd.lbci.net/ ), which includes diverse interactions for more than 8,000 drugs, 163 microbes, and 42 common diseases. Potential interactions between microbes and more than 8,000 drugs have been systematically studied by targeting microbial QS receptors combined with a docking-based virtual screening technique and in vitro experimental validations.

本研究开发了一套包含三个模块的系统化工作流程，用于构建基于群体感应（Quorum Sensing, QS）的药物-微生物-疾病（QS-DMD）数据库（网址：http://www.qsdmd.lbci.net/）。该数据库涵盖了8000余种药物、163种微生物以及42种常见疾病之间的多样化相互作用。研究团队以微生物QS受体为靶点，结合基于分子对接的虚拟筛选技术与体外实验验证，系统探究了微生物与8000余种药物之间的潜在相互作用。

搜集汇总

背景与挑战

背景概述

QS-DMD是一个专注于群体感应（QS）机制的数据集，包含超过8,000种药物、163个微生物集群和42种常见疾病之间的关联，旨在促进个性化医疗和潜在疾病疗法的研究。