Indexing of anti-fibrotic drugs from in vivo data.

All data are taken from the literature using dimethylnitrosamine (DMN) treatment, carbon tetrachloride (CCl4) treatment, or CCl4 preventive fibrotic rat models. Histological scores are linearly converted to a scale from 0 to 4. Ein vivo is established as shown. Drugs under each animal model are sorted according to increasing Ein vivo. Silymarin, malotilate and pioglitazone have the same relative ranking in CCl4 treatment and preventive models.