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Transcriptional characterisation of hemopoietic populations in GATA1s ESC-derived Megakarypoieisis

ChEBI2020-06-15 更新2026-07-12 收录

血细胞发育转录组学

巨核细胞分化

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-MTAB-8968 数据链接链接失效反馈

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Transcriptional characterisation of hemopoietic populations in GATA1s ESC-derived Megakarypoieisis

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创建时间：

2020-06-15

巨核细胞分化

依赖性基因表达

The molecular regulation of megakaryocytic differentiation is poorly understood. Using a myelogenous leukemia cell line, K562, which can partly recapitulate the process in response to phorbol 12-myri

NIAID Data Ecosystem100

Cell-autonomous function of Runx1 transcriptionally regulates megakaryocytic maturation in mice (expression)

巨核细胞分化

转录因子功能基因组学

RUNX1 transcription factor (TF) is a key regulator of megakaryocytic development and when mutated is associated with familial platelet disorder and predisposition to acute myeloid leukemia (FPD-AML).

NIAID Data Ecosystem50

A novel method for automated assessment of megakaryocyte differentiation and proplatelet formation

巨核细胞分化

血小板研究

Transfusion of platelet concentrates represents an important treatment for various bleeding complications. However, the short half-life and frequent contaminations with bacteria restrict the availabil

DataCite Commons2020-08-30 更新50

Megakaryocyte lineage development is controlled by modulation of protein acetylation

巨核细胞分化

蛋白质乙酰化与去乙酰化

Treatment with lysine deacetylase inhibitors (KDACi) for haematological malignancies, is accompanied by haematological side effects including thrombocytopenia, suggesting that modulation of protein ac

NIAID Data Ecosystem80

Notch Stimulates Both Self-Renewal and Lineage Plasticity in a Subset of Murine CD9 High Committed Megakaryocytic Progenitors

巨核细胞分化

Notch信号调控

This study aimed at reinvestigating the controversial contribution of Notch signaling to megakaryocytic lineage development. For that purpose, we combined colony assays and single cells progeny analys

NIAID Data Ecosystem50

Transcriptional characterisation of hemopoietic populations in GATA1s ESC-derived Megakarypoieisis

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