Spatial and Temporal Regulation of Gene Expression in the Mammalian Growth Plate

To explore the mechanisms responsible for spatial and temporal regulation of the growth plate, we microdissected postnatal rat growth plates into their constituent zones and then used microarray analysis to characterize the changes in gene expression that occur as chondrocytes undergo spatially-associated differentiation and temporally-associated senescence.为探究生长板时空调控的潜在分子机制，我们将新生大鼠的生长板显微解剖为其组成区域，并通过基因芯片（microarray）分析，对软骨细胞在空间依赖性分化与时间依赖性衰老过程中发生的基因表达变化进行了表征。