Pathway analyses of prostate biopsy tissue.

EGFR, epidermal growth factor receptor; GPCRs, G-protein coupled receptors; IL-2, interleukin 2; TGFβ, transforming growth factor beta; TURP, transurethral resection of the prostate; Wnt, wingless-type MMTV integration site. Pathways in GenMAPP that are enriched in the gene lists that differentiate groups are shown. Only pathways with adjusted P values ≤0.05 are shown. Also, the number of genes changing between groups that belong to these pathways is shown alongside the total number of genes that constitute the pathway. Pathway analysis was performed on gene lists generated in dChip that were statistically significant (P≤0.05, Welch modified two-sample paired or unpaired t-test) between the two groups. No fold cutoff was used. For details on gene lists see Table 3.
*P-values were calculated in GenMAPP using a non-parametric statistic based on 2000 permutations of the data and further adjusted for multiple testing by Westfall-Young adjustment.
**GSTM1 positive volunteers, n = 4.