Serotonin-induced hyperactivity in SSRI-resistant major depressive disorder patient-derived neurons

The goals of this study are to generate and study neurons from MDD patients and examine specific aspects of serotonergic neurotransmission in selective serotonin reuptake inhibitor (SSRI) remitters ® and SSRI-nonremitters (NR) From patients (NR, R) and healthy controls (H), forebrain neurons were derived from iPSCs for further study (Vadodaria et al, 2019)