Patient-specific models of dyssynchronous heart failure for assessment of regional work in patients undergoing cardiac resynchronization therapy

Cardiac resynchronization therapy (CRT) can improve the synchrony of contraction between the right and left ventricles in DHF and reduce morbidity and mortality and increase quality of life. However, regional work before CRT and changes with CRT are not well understood. We used three-dimensional multi-scale patient-specific computational models parameterized by anatomic, functional, hemodynamic, and electrophysiological measurements to assess changes in eight patients with heart failure and left bundle branch block (LBBB) who received CRT. To increase clinical translatability, we also explored the utility of streamlined methods to estimate regional myocardial work. We found that CRT increased global myocardial work efficiency with significant improvements in non-responders. Reverse ventricular remodeling after CRT was greatest in patients with the highest heterogeneity of regional work at baseline. Decreases in early-activated regions of myocardium performing negative myocardial work wi..., We built three-dimensional multi-scale patient-specific computational models parameterized by anatomic, functional, hemodynamic, and electrophysiological measurements in eight patients with heart failure and left bundle branch block (LBBB) who received CRT.
To increase clinical translatability, we also explored whether streamlined computational methods provide accurate estimates of regional myocardial work., , **Paper: Patient-Specific Models of Dyssynchronous Heart Failure for Assessment of Regional Work in Patients Undergoing Cardiac Resynchronization Therapy**

**Authors:**

Amanda Craine, Adarsh Krishnamurthy, Christopher T Villongco, Kevin Vincent, David E Krummen, Sanjiv M Narayan, Roy CP Kerckhoffs, Jeffery Omens, Francisco Contijoch, Andrew D McCulloch

**Description:**

This README file describes the data package accompanying the publication above. The data is split into two parent files corresponding to two different features of this study: Patient-Specific Modeling, and Simplified Work Estimates.

**File Structure**

**Patient-Specific Modeling Dataset:**

**Files:**

**Simulation Data** folder: This folder contains the simulation results for each subject of this study, separated by subject. Below is an example of the file structure and its contents for one subject. The same file structure applies to all subjects (BiV1-8).

**BiV1**: Biventricular simulation data for subject 1

*Pa...