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Crystal Structure of human PARP-1 ART domain bound to inhibitor UTT83

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Protein Data Bank Japan2024-11-13 更新2026-03-21 收录
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Crystal Structure of human PARP-1 ART domain bound to inhibitor UTT83 Descriptor: (2Z)-2-{[4-(3-cyclopropyl-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carbonyl)phenyl]methylidene}-3-oxo-2,3-dihydro-1-benzofuran-7-carboxamide, CHLORIDE ION, CITRIC ACID, ... Authors: Langelier, M.F, Pascal, J.M. Deposit date: 2019-01-23 Release date: 2019-08-14 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Design and Synthesis of Poly(ADP-ribose) Polymerase Inhibitors: Impact of Adenosine Pocket-Binding Motif Appendage to the 3-Oxo-2,3-dihydrobenzofuran-7-carboxamide on Potency and Selectivity. J.Med.Chem., 62, 2019
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2019-01-23
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