Dopamine receptor D2 antagonization normalizes the profibrotic macrophage-endothelial crosstalk in the liver

Fibrosis in the liver is a main histological determinant of non-alcoholic steatohepatitis (NASH), a disease paralleling a worldwide surge in metabolic syndrome. Our study demonstrates that myeloid-specific YAP deficiency attenuates liver fibrosis after chronic liver injury via boosting type I interferon. Dopamine receptor D2 (DRD2) antagonization selectively blocks YAP in macrophages and thwarts liver fibrosis in both rodent and large animal models. liver nonparenchymal cells scRNA sequence of fibrosis model wild type (WT) and yap1flox/floxlyz2cre mice