Table_1_Deep brain stimulation for Parkinson’s disease: bibliometric analysis of the top 100 cited literature.docx

BackgroundDeep Brain Stimulation (DBS) has been widely applied and accepted in the treatment of neurological and psychiatric disorders. Despite numerous studies exploring the effects of DBS on the progression of neurodegenerative diseases and the treatment of advanced Parkinson’s disease (PD), there is a limited number of articles summarizing this research. The purpose of this study is to investigate the current trends, hot topics, and potential in research surrounding DBS therapy for PD, as well as to anticipate the challenges of such research.MethodsWe searched the Web of Science Core Collection database (WoSCC) for DBS research literature related to PD published from January 2014 to January 2024, utilized CiteSpace, VOS viewer, the bibliometric online analysis platform, Scimago Graphica, Microsoft Excel 2021, and R software version 4.2.3 for data analysis. And we conducted quantitative research on publications, citations, journals, authors, countries, institutions, keywords, and references, visualized the results in network graphs.ResultsFrom 2014 to 2024, papers from 39 journals from 11 countries were among the top 100 cited. Most papers were published in Neurology, with the highest average citations per paper in Nature Neuroscience. The United States (US) contributed the most publications, followed by the United Kingdom (UK) and Germany. In terms of total publications, University College London (UCL) contributed the most papers. The primary classifications of articles were Clinical Neurology, Neurosciences, and Surgery. The top five keywords were subthalamic nucleus, DBS, PD, medical therapy, and basal ganglia. Cluster analysis indicates that DBS research focus on improving quality of life and applying computational models.ConclusionThrough bibliometric analysis, researchers could quickly and clearly understand the hotspots and boundaries of their research field, thus guiding their research direction and scope to improve research efficiency and the quality of outcomes. Although studies indicate that DBS is currently a crucial method for treating advanced PD, in the long run, creating a personalized, low-cost treatment regimen with precise targeting and long-term efficacy poses a challenge.

背景深度脑刺激（Deep Brain Stimulation，简称DBS）在神经和精神疾病的治疗中得到广泛应用和认可。尽管众多研究探讨了DBS对神经退行性疾病进展及晚期帕金森病（Parkinson’s disease，简称PD）治疗的影响，但总结此类研究的文献数量有限。本研究旨在探讨围绕DBS治疗PD的研究现状、热门话题及潜在价值，并预测此类研究可能面临的挑战。

方法：本研究检索了Web of Science核心合集数据库（WoSCC）中2014年1月至2024年1月发表的与PD相关的DBS研究文献，利用CiteSpace、VOS viewer、文献计量在线分析平台Scimago Graphica、Microsoft Excel 2021及R软件版本4.2.3进行数据分析。我们对出版物、引用、期刊、作者、国家、机构、关键词和参考文献进行了定量研究，并以网络图的形式可视化结果。

结果：2014年至2024年间，来自11个国家的39种期刊的论文入选了最高引用的前100篇。其中，大部分论文发表在《神经学》杂志上，平均每篇论文的引用量最高的为《自然神经科学》。美国（US）贡献了最多的出版物，其次是英国（UK）和德国。就总出版物数量而言，伦敦大学学院（University College London，简称UCL）贡献了最多的论文。文章的主要分类为临床神经学、神经科学和外科手术。前五位关键词分别为丘脑下核、DBS、PD、药物治疗和基底神经节。聚类分析表明，DBS研究的焦点在于提升生活质量及应用计算模型。

结论：通过文献计量分析，研究者能够迅速且清晰地了解其研究领域的研究热点和边界，从而指导其研究方向和范围，以提升研究效率和成果质量。尽管研究表明，DBS目前是治疗晚期PD的关键方法，但从长远来看，创建一种个性化、低成本、精准定位且长期有效的治疗方案仍面临挑战。