Supplementary Table S5 from BAP1 Loss Is Associated with DNA Methylomic Repatterning in Highly Aggressive Class 2 Uveal Melanomas

BAP1KDvsWT_HyperMethyl: All significantly hypermethylated probes (FDR < 0.05) with an absolute value (log2(RNA fold change)) > 1 and absolute value (methylation Delta Beta value) > 0.01 in BAP1KDvsWT 92.1 and Mel202 cells. BAP1KDvsWT_HypoMethyl: All significantly hypomethylated probes (FDR < 0.05) with an absolute value (log2(RNA fold change)) > 1 and absolute value (methylation Delta Beta value) > 0.01 in BAP1KDvsWT 92.1 and Mel202 cells. BAP1KD_HyperMeth_ChrLoc: Chromosomal loci enriched (FDR < 0.05) for top 1000 hypermethylated genes in BAP1KDvsWT 92.1 and Mel202 cells. BAP1KD_HypoMeth_ChrLoc: Chromosomal loci enriched (FDR < 0.05) for top 1000 hypomethylated genes in BAP1KDvsWT 92.1 and Mel202 cells. BAP1KD_HyperMeth_KEGG_REACTOME: Functional (KEGG and REACTOME) pathways enriched (FDR < 0.05) for top 1000 hypermethylated genes in BAP1KDvsWT 92.1 and Mel202 cells. BAP1KD_HypoMeth_KEGG_REACTOME: Functional (KEGG and REACTOME) pathways enriched (FDR < 0.05) for for top 1000 hypomethylated genes in BAP1KDvsWT 92.1 and Mel202 cells.

BAP1KDvsWT_HyperMethyl：在BAP1KDvsWT 92.1和Mel202细胞中，所有显著高甲基化的探针（FDR < 0.05）具备绝对值（log2（RNA变化倍数））大于1以及绝对值（甲基化Delta Beta值）大于0.01的特征。BAP1KDvsWT_HypoMethyl：在BAP1KDvsWT 92.1和Mel202细胞中，所有显著低甲基化的探针（FDR < 0.05）满足绝对值（log2（RNA变化倍数））大于1以及绝对值（甲基化Delta Beta值）大于0.01的条件。BAP1KD_HyperMeth_ChrLoc：在BAP1KDvsWT 92.1和Mel202细胞中，富含（FDR < 0.05）前1000个高甲基化基因的染色体位点。BAP1KD_HypoMeth_ChrLoc：在BAP1KDvsWT 92.1和Mel202细胞中，富含（FDR < 0.05）前1000个低甲基化基因的染色体位点。BAP1KD_HyperMeth_KEGG_REACTOME：在BAP1KDvsWT 92.1和Mel202细胞中，对于前1000个高甲基化基因，功能通路（KEGG和REACTOME）富集（FDR < 0.05）。BAP1KD_HypoMeth_KEGG_REACTOME：在BAP1KDvsWT 92.1和Mel202细胞中，对于前1000个低甲基化基因，功能通路（KEGG和REACTOME）富集（FDR < 0.05）。