Summary of results, demonstrating the change in the number of cell bodies in the SVZ, RMS, GCL and GL of 6-OHDA injected animals when compared to control.

Protocol 1. A single dose of BrdU (150 mg/kg i.p.) was administered 2 hours prior to death, 7 or 42 days after the 6-OHDA or NaCl injections (n = 4 for each experimental group) (see Fig. 2A). First symbol represents 7 day group; second symbol corresponds to 42 day group. Protocol 2. BrdU (50 mg/kg, i.p.) was administered twice daily for 3 consecutive days beginning 7 days after 6-OHDA (n = 4) or NaCl (n = 4) injections into the SNc, and mice killed 6 days later (i.e. 15 days after 6-OHDA administration) (see Fig. 2B). Protocol 3. BrdU (50 mg/kg, i.p.) was administered twice daily for 5 consecutive days, beginning 8 days after 6-OHDA (n = 4) or NaCl (n = 4) was injected into the SNc, and mice killed 30 days later (i.e. 42 days after 6-OHDA administration) (see Fig. 2C). ↓ corresponds to reduced number of cell bodies in comparison to control; ↑ corresponds to increased number of cell bodies; = corresponds to no statistical change in number of cell bodies. Numbers and letters in brackets refer to corresponding figure.