LARP7 suppresses endothelial-to-mesenchymal transition by coupling with TRIM28

LARP7 plays a pivotal role in regulating endothelial-to-mesenchymal transition(EndMT) and EndMT-associated heart valve formation. LARP7 directly interactes with TRIM28 and cooperatively represses SLUG transcription, which thereby suppresses EndMT of endothelial cells. More importantly, inducible knockout of LARP7 or TRIM28 in the endocardium promotes EndMT in vivo and leads to the valvular hyperplasia. Overall design: Examination of the chromatin occupancy of LARP7 and TRIM28 in Human umbilical endothelial cells