Luecken Cite-seq human bone marrow 2021 preprocessing

Dataset published by Luecken et al. 2021 which contains data from human bone marrow measured through joint profiling of single-nucleus RNA and Antibody-Derived Tags (ADTs) using the 10X 3' Single-Cell Gene Expression kit with Feature Barcoding in combination with the BioLegend TotalSeq B Universal Human Panel v1.0.
File Descriptioncite_quality_control.h5mu: Filtered cell by feature MuData object after quality control.cite_normalization.h5mu: MuData object of normalized data using DSB (denoised and scaled by background) normalization.cite_doublet_removal_xdbt.h5mu: MuData of data after doublet removal based on known cell type markers. Cells were removed if they were double positive for mutually exclusive markers with a DSB value >2.5.cite_dimensionality_reduction.h5mu: MuData of data after dimensionality reduction.cite_batch_correction.h5mu: MuData of data after batch correction.CitationLuecken, M. D. et al. A sandbox for prediction and integration of DNA, RNA, and proteins in single cells. Thirty-fifth Conference on Neural Information Processing Systems Datasets and Benchmarks Track (2021).
Original data linkhttps://openproblems.bio/neurips_docs/data/dataset/