FYN-mediated phosphorylation of GRIN2B

Kinase activity of FYN is needed for tyrosine phosphorylation of the GRIN2B (also known as NR2B or GluN2B) subunit of the NMDA receptor complex in response to BDNF-mediated activation of the NTRK2 (TRKB) receptor (Mizuno et al. 2003, Li et al. 2017). The exact stoichiometry of this reaction and involvement of other proteins is not known.<p>Based on studies in rats, phosphorylation of GRIN2B by FYN downstream of NTRK2 signaling plays an important role in long term potentiation (LTP) and spatial memory formation (Mizuno et al. 2003) as well as in spinal LTP and pain hypersensitivity after peripheral nerve injury (Li et al. 2017).

FYN激酶的活性对于NMDA受体复合体中GRIN2B（又称NR2B或GluN2B）亚单位的酪氨酸磷酸化至关重要，此过程响应于由BDNF介导的NTRK2（TRKB）受体激活（Mizuno等人，2003年，Li等人，2017年）。此反应的确切化学计量比以及其他蛋白质的参与情况尚不明确。基于大鼠的研究，FYN在NTRK2信号通路下游对GRIN2B的磷酸化在长期增强（LTP）和空间记忆形成（Mizuno等人，2003年）中起着重要作用，以及在外周神经损伤后的脊髓LTP和痛觉过敏（Li等人，2017年）中亦扮演关键角色。