Excessive Firing of Dyskinesia-Associated Striatal Direct Pathway Neurons is Gated By Dopamine and Excitatory Synaptic Input

This folder contains data associated with a submitted manuscript: Ryan, Girasole et al, which was first posted on BioRxiv in 2022. https://www.biorxiv.org/content/10.1101/2022.10.31.514594v1.

Files associated with each figure: 

Figure 1 & Supp Figure 1:  

Summary.mat

Behavior.mat

Data.mat

TRAP_InVivo_Analysis.m

TRAP_Remove_INs.m

Figure 2 & Supp Figure 2: 

See BioStudies for rabies dataset: https://www.ebi.ac.uk/biostudies/studies/S-BSST1374?key=9a1b2103-25a6-49ed-b257-0269d3ea19a6

Figure 3 & Supp Figure 3 & Supp Figure 4: 

Fig3_FigS3_FigS4_Data.xlsx

Figure 4 & Supp Figure 5: 

Fig4Data.xlsx

RNAscopeAnalysis_D1_D2.m

RNAdata.mat

RNAscopeAnalysis_D1_pDyn.m

RNAScopeAnalysis.m

pDynRNAdata.mat

pDynSummary.mat

Contributions: 

Behavioral data was collected and analyzed by Ally Girasole, Michael Ryan, and Emily Twedell.

In vivo electrophysiological data was collected and analyzed by Michael Ryan and Ally Girasole.

Ex vivo electrophysiological data was collected and analyzed by Ally Girasole, Michael Ryan, Emily Twedell, and Alexandra Nelson.

Anatomical tracing and histology data was collected and analyzed by Ron Paletzki, Chip Gerfen, Michael Ryan, Ally Girasole and Rea Brakaj.

RNA Scope data was collected and analyzed by Andrew Flores, Mike Ryan, and Tom Hnasko.