Single-cell analysis of childhood leukemia reveals a link between developmental states and ribosomal protein expression as a source of intra-individual heterogeneity

Assessing intra-individual transcriptional heterogeneity in cALL patients using single cell RNA-seq Overall design: 10X Genomics 3' single cell RNA-seq: Pre-B t(12;21) [ETV6-RUNX1] acute lymphoblastic leukemia, Pre-B High hyper diploid [HHD] acute lymphoblastic leukemia, Pre-T acute lymphoblastic leukemia, Healthy pediatric bone marrow mononuclear cells. Annotations.tsv contains sample, cell cycle phase, tSNE/UMAP coordinates, and assigned cell type.