Cardiac gene expression after transgenic overexpression or deletion of MeCP2 in cardiomyocytes. Mus musculus

To identify potentially regulated target genes of MeCP2 we used celltype-specific models for transgenic overexpression and ablation of MeCP2. Gene expression was analyzed in cardiac biopsies of adult male mice. The study contains three different treatment groups: 1. healthy mice (Sham), 2. mice suffering from 4-6 weeks of cardiac pressure overload (TAC) and 3. with a reversible induction of TAC (TAC followed by 2 weeks without TAC) Overall design: In all experiments we added the corresponding WT for the muted strains. The three different disease conditions were performed individually and thus the results are not directly comparable.