Next Generation Sequencing of Wild Type and CMG2-/- Rat Lung Transcriptomes

Conclusion Our work identifies a novel role for CMG2 in systemic-to-pulmonary shunt induced PAH based on the findings that CMG2 deficiency could exacerbate systemic-to- pulmonary shunt induced vascular remodeling in the development of PAH. CMG2 may be a potential target for CHD-PAH treatment.结论 本研究明确了CMG2在体-肺分流诱导的肺动脉高压（Pulmonary Arterial Hypertension, PAH）中的全新作用，研究依据为：CMG2缺失可加剧体-肺分流诱导的肺动脉高压发生发展过程中的血管重构。CMG2有望成为先天性心脏病相关性肺动脉高压（Congenital Heart Disease-Pulmonary Arterial Hypertension, CHD-PAH）的潜在治疗靶点。