Chiral Amide Directed Assembly of a Diastereo- and Enantiopure Supramolecular Host and its Application to Enantioselective Catalysis of Neutral Substrates

The
synthesis of a novel supramolecular tetrahedral assembly of K12Ga4L6 stoichiometry is reported. The
newly designed chiral ligand exhibits high diastereoselective control
during cluster formation, leading exclusively to a single diastereomer
of the desired host. This new assembly also exhibits high stability
toward oxidation or a low pH environment and is a more robust and
efficient catalyst for asymmetric organic transformations of neutral
substrates.