One-Pot Synthesis of Functionalized Piperid-4-ones: A Four-Component Condensation
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https://figshare.com/articles/dataset/One_Pot_Synthesis_of_Functionalized_Piperid_4_ones_A_Four_Component_Condensation/2930314
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资源简介：
The one-pot synthesis of highly substituted piperid-4-ones has been achieved. Diketene is added to a tosyl imine in the presence of TiCl4 and MeOH, followed by 1 equiv of aldehyde to generate 2,6-disubstituted nonsymmetrical piperid-4-ones as a mixture of cis-/trans-diastereomers in good yields. This mixture of diastereomers can be converted to a single 2,6-cis-diastereomer by epimerization with K2CO3.
创建时间：
2016-02-27
