The mouse genome displays highly dynamic populations of KRAB-zinc finger protein genes and related genetic units
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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We present a thorough analysis of KZFP genes and related units in the murine genome. We first identified about twice more elements than previously annotated either as KZFP genes or pseudogenes, we then could delineate an organization in clusters distributed throughout the genome, with signs of recombination, translocation, duplication and seeding of new sites by retrotransposition of KZFP genes and related genetic units (KZFP/rGUs). Finally, we could demonstrate that the KAP1-SETDB1 repressor complex tames the expression of KZFP/rGUs within clusters, yet that the primary target of this regulation was not the KZFP/rGUs themselves but enhancers contained in neighboring endogenous retroelements.
提供机构：
EPFL
创建时间：
2022-02-20
