Mutations identified in JFH1/RFP replicons after selection for DEBIO-025 resistance.

aNumber of DNA clones in which the mutation was found vs. number of clones that were analyzed. Note that all mutations were found with the 3�� PCR fragment (Fig. 6A) and therefore the identified mutations coexisted in the same replicon RNA.bAmino acids found at the corresponding position of the polyprotein of HCV isolates available in the European HCV database and belonging to genotypes 1a,b,c; 2a,b,c,i,k; 3a,b,k; 4a,d,f; 5a; 6a,b,c,e,f,g,h,i,j, k,l,m,n,p; 7a.cVirus titer enhancing mutation; data taken from [40].n.a., not applicable.Bracketed numbers refer to positions of the individual HCV protein of the JFH1 isolate.