Expression data from wild type, mre11delta, rad50delta, and spo11Y135F at meiosis 0 hr and 4 hr.

Mre11, together with Rad50 and Xrs2/NBS, plays pivotal roles in homologous recombination, repair of DNA double strand breaks (DSBs), activation of damage-induced checkpoint, and telomere maintenanceMre11（Mre11）与Rad50（Rad50）及Xrs2/NBS复合物（Xrs2/NBS）协同作用，在同源重组（homologous recombination）、DNA双链断裂（DSBs）修复、损伤诱导检验点（damage-induced checkpoint）激活以及端粒维持（telomere maintenance）过程中发挥至关重要的作用。