Parameters of all Asn and Asp sites in mouse and human α-synuclein.

aHalf-lives are those reported for synthetic pentapeptides containing the trimer sequence shown, and bounded by a glycine at each end [6]. Values for the two Asn residues unique to the human sequence are bold-faced.bAverage flexibilities for mouse and human sequences were calculated using ProtScale at www.ExPASy.com with a 7-residue moving window and normalization to a scale of 0–1.cSame as (a) above for three widely reported hot-spot sequences in peptides and proteins.