Expression changes in respiratory epithelial cells when treated with TGF-β1

TGF-β1 is involved in various biological processes through downstream signals including SMAD, Akt, Erk, etc. TGF-β1 overexpressed by harmful stimuli can act as a causative factor in diseases such as accumulation of extracellular matrix and development of cancerous characteristics. Therefore, we sought to compare changes in expression of intracellular miRNAs to study diseases caused by TGF-β1. In our study, we aimed to discover therapeutic targets for TGF-β1-induced disease by investigating changes in miRNA expression and identifying the correlation between genes that can be regulated by miRNA. To investigate changes in the expression of two respiratory epithelial cells according to TGF-β1 exposure, A549 and BEAS-2B were treated with TGF-β1 at 1 and 5 ng/mL for 2 days.