Data_Sheet_1_Sex-specific association of serum uric acid trajectories with risk of incident retinal arteriosclerosis in Chinese population: A population-based longitudinal study.doc

BackgroundThe impact of serum uric acid (SUA) trajectories on the development of retinal arteriosclerosis is uncertain. The purpose of this study was to identify adult SUA trajectories by sex and determine their association with risk of retinal arteriosclerosis.MethodsIn this longitudinal study, 4,324 participants who were aged between 18 and 60 years without retinal arteriosclerosis at or before baseline (from January 1, 2010, through December 31, 2010) were included. Group-based trajectory modeling was used to identify SUA trajectories during the exposure period (from January 1, 2006, through December 31, 2010). Cox proportional-hazards models were applied to evaluate the associations between SUA trajectories and the risk of incident retinal arteriosclerosis during the outcome period (from January 1, 2011, through December 31, 2019).Results4 distinct SUA trajectories were identified in both women and men: low, moderate, moderate-high, and high. During a median follow-up of 9.54 years (IQR 9.53–9.56), 97 women and 295 men had developed retinal arteriosclerosis. In the fully adjusted model, a significant association between the moderate-high SUA trajectory group and incidence of retinal arteriosclerosis was observed only in men (HR: 1.76, 95% CI: 1.17–2.65) compared with the low trajectory group, but not in women (HR: 0.77, 95% CI: 0.39–1.52). Also, the high SUA trajectory group had the highest risk with an adjusted HR of 1.81 (95% CI, 1.04–3.17) in men. However, they did not exhibit a substantially increased risk in women.ConclusionHigher SUA trajectory groups were significantly associated with an increased risk of incident retinal arteriosclerosis in men but not in women.

背景：血清尿酸（SUA）轨迹对视网膜动脉硬化发展的影响尚不明确。本研究旨在按性别识别成年人的SUA轨迹，并确定其与视网膜动脉硬化风险之间的关联。方法：在本项纵向研究中，纳入了4,324名在基线时（自2010年1月1日至2010年12月31日）及之前未患有视网膜动脉硬化的18至60岁参与者。利用基于群体的轨迹模型，在暴露期间（自2006年1月1日至2010年12月31日）识别SUA轨迹。通过Cox比例风险模型，评估SUA轨迹与结局期间（自2011年1月1日至2019年12月31日）新发视网膜动脉硬化风险之间的关联。结果：在男性和女性中均识别出4种不同的SUA轨迹：低、中、中高和高。在平均随访9.54年（四分位数间距9.53-9.56）期间，97名女性和295名男性发生了视网膜动脉硬化。在完全调整模型中，仅观察到中高SUA轨迹组与视网膜动脉硬化发病率之间存在显著关联，且仅限于男性（HR：1.76，95% CI：1.17-2.65），与低轨迹组相比，但在女性中并未观察到（HR：0.77，95% CI：0.39-1.52）。此外，高SUA轨迹组在男性中的调整HR最高，为1.81（95% CI，1.04-3.17）。然而，在女性中，他们并未显示出风险显著增加。结论：较高的SUA轨迹组与男性而非女性新发视网膜动脉硬化风险的增加显著相关。