Thy1-p45 transgenic mice have decreased retraction of CST fibers and improved functional recovery following SCI compared to their WT littermates.

(A–F) Representative pictures of the YFP-labeled CST fiber front near the lesion epicenter following SCI in the WT littermates (A, B) and Thy1-p45 transgenic mice (C–F). The lesion epicenter is indicated by a vertical dashed line (A and C). (B) A higher magnification of boxed region in (A). (D) A higher magnification of boxed region in (C). (E, F) Higher magnifications of boxed regions in (D). Compared to their WT littermates, the CST fiber front in Thy1-p45 transgenic mice is closer to the lesion epicenter and has increased sprouting (arrows) near the lesion site. Scale bars: 200 µm (A, C), 100 µm (B, D) and 50 µm (E, F). (G) Quantitative analysis of distance between the CST fiber front and the lesion epicenter following SCI. WT littermates, n = 18 (6 mice, 3 sections/mouse), Thy1-p45 transgenic mice, n = 27 (9 mice, 3 sections/mouse). (H) Comparison of the locomotor activity in WT littermates and Thy1-p45 transgenicmice using the BMS scoring system. *P