Endocardial HDAC3 is required for myocardial trabeculation [single-cell RNA-seq]

To investigate the signal communication from the endocardium to the trabecular myocardium, we performed single cell RNA sequencing (scRNA-seq) in E11.5 Hdac3 Tie2 knockout hearts and littermate control hearts In E11.5 Hdac3 Tie2 knockout hearts and littermate control hearts, single cells are isolated and analyzed using single cell RNA sequencing (scRNA-seq)为探究心内膜向小梁心肌传递的信号通讯机制，我们对胚胎第11.5天（E11.5）的Hdac3 Tie2基因敲除心脏及其同窝对照心脏开展了单细胞RNA测序（single cell RNA sequencing，scRNA-seq）实验。在上述两类心脏中，研究人员均分离得到单细胞并通过scRNA-seq完成分析。