Role of rsc2 in nucleotide excision repair in yeast

Nucleosomes are a significant barrier to the repair of UV damage because they impede damage recognition by nucleotide excision repair (NER). The RSC chromatin remodeler functions in cells to promote DNA access by moving or evicting nucleosomes and has been linked to NER in yeast. Here, we report genome-wide repair maps of UV-induced cyclobutane pyrimidine dimers (CPDs) in yeast cells lacking Rsc2.核小体（Nucleosomes）是紫外线损伤修复的重要屏障，因其会阻碍核苷酸切除修复（nucleotide excision repair, NER）对损伤的识别。RSC染色质重塑复合物（RSC chromatin remodeler）可在细胞中通过移动或移除核小体来提升DNA可及性，且在酵母中与核苷酸切除修复通路相关联。本研究报道了缺失Rsc2的酵母细胞内，紫外线诱导的环丁烷嘧啶二聚体（cyclobutane pyrimidine dimers, CPDs）的全基因组修复图谱。