Replication data for "rSIREM: an R package for MALDI spectral deconvolution"
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https://dataverse.csuc.cat/citation?persistentId=doi:10.34810/data1744
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Replication data for the publication: "rSIREM: an R package for MALDI spectral deconvolution" by Del Castillo Pérez et al.
The deposited data are SALDI-MSI data of three consectutive thin tissue sections from mouse cerebellum measured at the different mass resolutions at the same instrument (MALDI-MSI: Spectroglyph Injector - Orbitrap Exploris).
The paper describes a new R package (rSIREM) to computationally improve the mass resolution of an MSI post-measurement.
The developed R package (https://github.com/EdelCastillo/rSirem ) applies a statistical treatment on the concentration of spatial images obtained by separately considering each of the m/z over all the pixels. A representative scalar is associated with each image, obtained by applying a new measure (SIREM) to it, derived from Shannon's entropy. The perturbations of this measure, when considering a sequence of consecutive images, reveal the existence of overlap, if it exists. This information serves as a seed to initialize the EM algorithm in the Gaussian Mixture Model context. The efficiency of the method has been verified using three independent procedures.
提供机构:
CORA.Repositori de Dades de Recerca
创建时间:
2024-09-16



