RNA-Seq, WGS, WXS of mouse myeloma tumors derived from Vk*MYC transgenic mice

Comprehensive genomic analysis (WXS, WGS, RNAseq) identifies shared pathways of progression between human and mouse myeloma. De novo myeloma tumors develop in aged Vk*MYC MYC transgenic mice (summarized by "_O_" in sample name). They may be located in extramedullary locations such as spleen ("_EM_"), or intramedullary in the bone marrow ("_BM_"). They can be passaged in recipient mice ("_R_"). Rarely we are able to establish cell lines that can grow in vitro ("_V_"). Tumors from the mice undergo CD138-selection and are analyzed by RNA-Seq, WGS and WXS