Effect of antipsychotic drugs on p110δ enzymatic activity

The effect of antipsychotic drugs (haloperidol, clozapine, olanzapine, quetiapine and amisulpride) on PI3Kdelta was tested with a kinase assay. The enzyme, which was used in the experiments was N-terminal His6-tagged recombinant, full-length, human p110delta associated with regulatory subunit p85alpha. The data presents luminescence of experimental wells as well as that of corresponding no-enzyme control wells in ADP-Glo Kinase Assay. The data includes all the experiments for the tested antipsychotic drugs.