Effect of KCNQ1 variants rs151290, rs2237892 and rs2237895 on beta-cell function as assessed with hyperglycaemic clamp.

aAdjusted for glucose tolerance status (NGT/IGT), study center, age, gender and BMI.All variables were log-transformed before analysis. p-values were computed for different additive models using linear generalized estimating equations (GEE) which takes into account the family relatedness when computing the standard errors. Alleles in bold are the risk alleles for type 2 diabetes identified by previous studies.DI, disposition index; IGT, impaired glucose tolerance; ISI, insulin sensitivity index; ND, not determined; NGT, normal glucose tolerance.