Reference intervals for serum 11-oxygenated androgens in children

This dataset corresponds to the article ‘Reference intervals for serum 11-oxygenated androgens in children’ (DOI: 10.1093/ejendo/lvae008.) published in the European Journal of Endocrinology (EJE).

This study aimed to establish pediatric reference values for eight androgens, including four 11-oxygenated androgens. For this purpose, a liquid-chromatography tandem mass spectrometry (LC-MS/MS) assay was developed and validated for clinical use. To establish pediatric reference values, we measured these androgens in 256 children. Blood was taken from these children before minor surgery or medical procedure. This group of children was previously described in ‘Standardized serum hepcidin values in Dutch children: Set point relative to body iron changes during childhood’ (DOI: 10.1002/pbc.28038). Data on demographics of the included patients can be requested by contacting the corresponding author of that article.

This dataset only comprises the patient number, the age (in years), and the concentrations (in nmol/L) of eight androgens: dehydroepiandrosterone (DHEA), androstenedione (A4), testosterone (TES), dihydrotestosterone (DHT), 11-hydroxyandrostenedione (11OHA4), 11-ketoandrostenedione (11KA4), 11-hydroxytestosterone (11OHT), and 11-ketotestosterone (11KT). Concentration below the lower limit of quantification (LLOQ) with a signal-to-noise (S/N) ratio ≤5 are given as half the LLOQ-value. Concentrations <LLOQ with a S/N-ratio >5 are given as absolute measured value.